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Description
NFAT1 Recombinant Rabbit mAb (S-1797-224)Product Specification Host Rabbit Antigen NFAT1 Synonyms Nuclear factor of activated T cells, cytoplasmic 2; NF ATc2; NFATc2; NFAT pre existing subunit (NF ATp); T cell transcription factor NFAT1; NFAT1; NFATP Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q13469 Clone Number S 1797 224 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample Daudi, Ramos, Raji, EL4, rat brain Purification
Product Specification
| Host | Rabbit |
| Antigen | NFAT1 |
| Synonyms | Nuclear factor of activated T-cells, cytoplasmic 2; NF-ATc2; NFATc2; NFAT pre-existing subunit (NF-ATp); T-cell transcription factor NFAT1; NFAT1; NFATP |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q13469 |
| Clone Number | S-1797-224 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Daudi, Ramos, Raji, EL4, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
Background
NFAT1 (Nuclear Factor of Activated T-cells 1) is a ~115 kDa transcription factor of the NFAT family that, upon cooperative binding of Ca²⁺/calmodulin-activated phosphatase calcineurin to its conserved PxIxIT and LxVP motifs, undergoes rapid dephosphorylation at multiple serine-rich motifs within its regulatory domain, exposing a nuclear localization sequence that drives its translocation from cytosol to nucleus where it cooperates with Fos/Jun, GATA, and IRF transcription partners to bind the consensus DNA element 5’-A/GAAGGAAA-3’ and activate transcription of cytokine genes (IL-2, IL-4, TNF-α), surface receptors (CD40L), and developmental regulators, while its activity is terminated by glycogen synthase kinase-3β (GSK-3β) and casein kinase-1 (CK1)-mediated re-phosphorylation followed by Crm1-dependent nuclear export; dysregulated NFAT1 signaling contributes to cardiac hypertrophy, autoimmune pathologies, and neoplastic growth, making calcineurin–NFAT1 interaction a pharmacological target of immunosuppressive drugs such as cyclosporine A and tacrolimus.
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