Mouse Anti-Human CD57 Antibody (S-3011)
SKU: 38542318888

Mouse Anti-Human CD57 Antibody (S-3011)

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Description

Mouse Anti-Human CD57 Antibody (S-3011)Product Specification Host Mouse Antigen CD57 Synonyms HNK 1; Leu 7 Location Cell membrane Clone Number S 3011 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution

Product Specification


Host Mouse
Antigen CD57
Synonyms HNK-1; Leu-7
Location Cell membrane
Clone Number S-3011
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CD57 (also designated HNK-1 or Leu-7) is not a protein per se, but a carbohydrate epitope synthesized by the enzymatic action of beta-1,3-glucuronyltransferase 1 (B3GAT1), a type-II membrane protein encoded by the B3GAT1 gene on chromosome 11q25; this enzyme transfers glucuronic acid to terminal N-acetyllactosamine to form the sulfated CD57 determinant on a variety of cell-surface proteins, lipids and chondroitin sulfate proteoglycans, conferring the antigen that marks subsets of terminally differentiated natural killer and CD8+ cytotoxic T lymphocytes, as well as certain neural and muscle cells, and is implicated in neural cell adhesion and the delineation of late-stage lymphocyte maturation.

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SKU: 38542318888

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